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Series GSE17735 Query DataSets for GSE17735
Status Public on Nov 24, 2009
Title Analysis of altered gene expressions in valproate-treated Disc1-L100P mutant mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Microarray analysis revealed that changes in genes expressions are brain region-dependent; expression of several genes are affected by point mutation L100P, which was verified by RT-PCR (Lcn2, Cyr61, Slc6a12, Slc40a1, Egr2), a few genes are affected by genotype and valproate (Dusp1 and Purb), suggesting their role in valproate-induced benificial effect on sensorimotor gaiting in Disc1-L100P mutant mice. The final conclusion will be drawn after series of RT-PCR confirmation.

Keywords: drug response and genetic modification
 
Overall design Unequal two-factor, two-level experiment with drug/control and genetic-variation/wild-type as the factors. 4 datasets of 4 different tissues
 
Contributor(s) Lipina TV, Haque FN, Boutros PC, Wong AH, Roder JC
Citation(s) 20687111
Submission date Aug 20, 2009
Last update date Jun 14, 2018
Contact name Paul C Boutros
E-mail(s) Paul.Boutros@utoronto.ca
Organization name Ontario Institute for Cancer Research
Street address 101 College Street, Suite 800
City Toronto
State/province Ontario
ZIP/Postal code M5G 0A3
Country Canada
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (69)
GSM442747 BS-Wildtype-Vehicle-rep1
GSM442748 BS-Wildtype-Vehicle-rep2
GSM442749 BS-Wildtype-Vehicle-rep3
Relations
BioProject PRJNA118389

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE17735_RAW.tar 4.3 Gb (http)(custom) TAR (of TIFF, TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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