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| Status |
Public on Jun 17, 2021 |
| Title |
Transcriptome-wide Gene Expression Analysis in Peri-Implantitis Reveals Candidate Cellular Pathways |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Transcriptome analysis of oral tissue samples taken from peri-implantitis and healthy control patients
Peri-implantitis is a condition resulting in destructive inflammation in the peri-implant soft tissue barrier. Clinically, it demonstrates vast clinical differences to periodontitis that suggests distinct inflammatory mechanisms. Implant-derived Titanium particles (i-TiPs) frequently found around diseased implants appear to alter the microenvironment and confer resistance to antibiotic treatments. Studies in orthopedic implants have demonstrated a strong inflammatory response to i-TiPs, involving a variety of cell types, in aseptic conditions. Nonetheless, the genetic programs of cells surveilling and supporting the peri-implant soft tissue barrier in response to the combined challenges of biomaterial degradation products and oral bacteria are poorly defined. Thus, we studied gene expression specific to oral peri-implant inflammatory disease. We found that certain cellular pathways were highly upregulated in diseased tissues. Upregulated pathways provided insight into important physiological pathways that might play a role in peri-implant pathology. These findings could potentially contribute to the production of more targeted and effective therapeutics for the disease.
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| Overall design |
We performed transcriptomic analysis on peri-implant soft tissue from 3 healthy implant controls and 4 peri-implantitis patients. Array data was processed by Affymetrix Exon Array Computational Tool with the use of the Summarization Signal Space Transformation - Robust Multichip Analysis (SST-RMA) algorithm.
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CHP file not provided for Well A12 Sample
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| Contributor(s) |
Alexander M, Georgios K, Peng Z |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jun 16, 2021 |
| Last update date |
Jun 20, 2021 |
| Contact name |
Georgios Kotsakis |
| E-mail(s) |
kotsakis@uthscsa.edu
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| Phone |
2108448900
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| Organization name |
UT Health San Antonio
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| Department |
Periodontics
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| Lab |
Dr. Kotsakis
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| Street address |
7703 Floyd Curl Dr.
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| City |
San Antonio |
| State/province |
TX |
| ZIP/Postal code |
78229 |
| Country |
USA |
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| Platforms (1) |
| GPL23159 |
[Clariom_S_Human] Affymetrix Clariom S Assay, Human (Includes Pico Assay) |
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| Samples (7)
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| Relations |
| BioProject |
PRJNA738533 |
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