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| Status |
Public on Sep 04, 2009 |
| Title |
Gene expression profiles from nandrolone-treated rats with denervation |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
We showed that nandrolone attenuated subacute, but not acute, denervation atrophy and upregulation of MAFbx. The present study explored the molecular determinants for this time-dependent effect using microarray analysis to identify genes that were differentially regulated by administration of nandrolone for 7 days beginning either concomitantly with denervation (7 days) or 29 days later (35 days)
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| Overall design |
The analysis used gastrocnemius muscle from male Wistar-Hannover rats that had undergone left sciatic nerve transaction followed by the administration of nandrolone or vehicle beginning either on the day of surgery or 29 days thereafter. Animals had been sacrificed 7 days after starting nandrolone (Nan) or vehicle (Veh) (e.g, at days 7 or 35).
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| Contributor(s) |
Cardozo C, Qin W, Bauman WA, Pan J |
| Citation(s) |
22208735, 20969782 |
| Submission date |
Sep 03, 2009 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Weiping Qin |
| E-mail(s) |
weiping.qin@mssm.edu
|
| Organization name |
Bronx Veterans Affairs Medical Center
|
| Department |
Center of Excellence for the Medical Consequences of SCI
|
| Street address |
130 West Kingsbridge Road, Room 1E-02
|
| City |
Bronx |
| State/province |
NY |
| ZIP/Postal code |
NY 10468 |
| Country |
USA |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA119923 |
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