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| Status |
Public on Sep 05, 2009 |
| Title |
Novel treatment of human pancreatic cancer using masitinib combined with standard gemcitabine chemotherapy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Masitinib is a tyrosine kinase inhibitor of c-Kit, PDGFRα and β, and to some extent Lyn of the Src kinase family. We evaluated the therapeutic potential of masitinib in vitro on human pancreatic tumour cell lines and in vivo in a mouse model of human pancreatic cancer.
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| Overall design |
Expression patterns of masitinib tyrosine kinase targets including c-Kit, PDGFRα and PDGFRβ were determined in four pancreatic tumour cell lines by PCR. Proliferation assays were performed with masitinib alone or in combination with gemcitabine. To determine the in vivo effects of masitinib, Nog-SCID mice were injected subcutaneously with MiaPaca2 cells, randomised 28 days later and received one of the following treatments: vehicle control p.o., masitinib p.o., gemcitabine i.p., or a combination of masitinib plus gemcitabine. Additionally, the transcriptome of MiaPaca2 cells for each of these conditions was determined with Affymetrix arrays.
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| Contributor(s) |
Hermine O, Moussy A, Castéran N, Letard S, Iovana J, Finetti P, Bertucci F, Bader T, Humbert M, Dubreuil P |
| Citation(s) |
20209107, 22110708 |
| Submission date |
Sep 04, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Pascal FINETTI |
| E-mail(s) |
finettip@ipc.unicancer.fnclcc.fr
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| Phone |
(33)+4 91 22 33 04
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| Organization name |
Institut Paoli-Calmettes
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| Department |
Centre de cancérologie de Marseille
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| Lab |
Molecular Oncology
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| Street address |
232 Bd Ste Marguerite
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| City |
Marseille |
| State/province |
BdR |
| ZIP/Postal code |
13009 |
| Country |
France |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA120021 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE17987_RAW.tar |
18.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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