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Series GSE17992 Query DataSets for GSE17992
Status Public on Nov 28, 2011
Title Effects of dexamethasone on human skeletal muscle and adipose tissue
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Context: Glucocorticoids are frequently prescribed drugs with important side-effects such as glucose intolerance and tissue remodelling.
Objective: The goal was to explore the molecular basis of the crosstalk between adipose tissue and skeletal muscle during short term glucocorticoid treatment.
Design and Intervention: Healthy male subjects were assigned to a 4-d treatment with dexamethasone at 4mg/d.
Main Outcome Measures: Primary outcome measures were gene expression profiling of adipose tissue and skeletal muscle. Urinary cortisol and metabolic biochemistry were also assessed.
 
Overall design Dexamethasone was provided in 0.5 mg tablets as 4mg per day during 4 days to male healthy volunteers. Skeletal muscle and adipose tissue biopsies were obtained at the beginning and at the end of the protocol. The transcriptome analysis compared before vs. after the 4 days dexamethasone treatment using a dye swap design and whole genome 4x44k oligonucleotide arrays (Agilent Technologies).
 
Contributor(s) Viguerie N, Picard F, Hul G, Roussel B, Barbe P, Iacovoni J, Valle C, Langin D, Saris W
Citation(s) 22108209
Submission date Sep 07, 2009
Last update date Feb 22, 2018
Contact name Nathalie Viguerie
Organization name INSERM
Department I2MC U1297
Lab MetaDiab
Street address Avenue Poulhes
City Toulouse
ZIP/Postal code 31400
Country France
 
Platforms (1)
GPL4133 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version)
Samples (27)
GSM433633 Effects of dexamethasone on human skeletal muscle BL rep
GSM446267 Effects of dexamethasone on human skeletal muscle BL
GSM446418 Effects of dexamethasone on human skeletal muscle BS
Relations
BioProject PRJNA119909

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Supplementary file Size Download File type/resource
GSE17992_RAW.tar 290.3 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table
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