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| Status |
Public on Apr 27, 2022 |
| Title |
The effect of periodontitis - induced trained immunity on the transcriptomic profile of mouse LSK cells [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Hematopoietic stem and progenitor cells (HSPCs) in the bone marrow can sense peripheral inflammation and adapt through expansion and skewing toward the myeloid lineage. In this study, we performed RNA sequencing in LSK (Lin—Sca-1+cKit+ ) cells to determine the impact of ligature-induced periodontitis on the transcriptomic profile of HSPCs in mice bone marrow.
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| Overall design |
C57BL/6 mice were subjected, or not (Non-ligature, NL), to ligature-induced periodontitis (LIP) for 7 days. Mice bone marrow were harvsted and LSKs were FACS-sorted and subjected to RNA-sequencing and transcriptome analysis.
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| Contributor(s) |
Li X, Yu X, Hajishengallis G |
| Citation(s) |
35483374 |
| Submission date |
Jul 13, 2021 |
| Last update date |
Jul 28, 2022 |
| Contact name |
George Hajishengallis |
| Organization name |
University of Pennsylvania
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| Street address |
School of Dental Medicine
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| City |
Philadelphia |
| State/province |
PA |
| ZIP/Postal code |
19104 |
| Country |
USA |
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| Platforms (1) |
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| Samples (6)
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| This SubSeries is part of SuperSeries: |
| GSE180032 |
The effect of periodontitis - induced trained immunity |
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| Relations |
| BioProject |
PRJNA746249 |
| SRA |
SRP328158 |
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