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| Status |
Public on Oct 13, 2021 |
| Title |
Profiling mRNA transcriptomic changes using Affymetrix Clarion D assay in 6 regions of postmortem brains of subjects with alcohol use disorder |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Chronic alcohol consumption may alter mRNA transcriptomic changes in reward-related brain regions, leading to neuroadaptations and thus increased risk of AUD.
We used the Affymetrix Clariom™ D Assay Array to map mRNA transcriptome profiles in six reward-related regions of postmortem brains of AUD and control subjects and identified differentially expressed mRNAs.
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| Overall design |
Total RNAs were extracted from tissue samples dissected from six regions (amygdala, caudate nucleus, cerebellum, hippocampus, prefrontal cortex, and putamen) of postmortem brains of 8 male patients with alcohol use disorder (AUD) and 8 male control subjects. Both AUD patients and control subjects were assessed with DSM-IV. The Affymetrix Clarion D microarray data was processed using the Expression Console (EC) software.
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| Contributor(s) |
Huiping Z |
| Citation(s) |
34601489 |
| Submission date |
Jul 23, 2021 |
| Last update date |
Oct 14, 2021 |
| Contact name |
Huiping Zhang |
| E-mail(s) |
huipingz@bu.edu
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| Phone |
6173583689
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| Organization name |
Boston University School of Medicine
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| Department |
Psychiatry
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| Street address |
72 East Concord Street
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| City |
Boston |
| State/province |
Massachusetts |
| ZIP/Postal code |
02118 |
| Country |
USA |
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| Platforms (1) |
| GPL23126 |
[Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version] |
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| Samples (96)
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| Relations |
| BioProject |
PRJNA749289 |
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