|
| Status |
Public on Jan 29, 2010 |
| Title |
Effects of moderate ethanol consumption during pregnancy on placental gene expression |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
We conducted a preliminary investigation to determine whether ethanol-induced alterations in placental gene expression may have some utility as a diagnostic indicator of maternal drinking during pregnancy as well as a prognostic indicator of risk for adverse neurobehavioral outcomes in affected offspring.
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| |
|
| Overall design |
Pregnant Long-Evans rats voluntarily consumed either a 0% or 5% ethanol solution four hours each day throughout gestation. Ethanol consumption produced a mean maternal daily intermittent peak serum ethanol concentration of 84 mg/dL. Placentas were harvested on Gestational Day 20 for gene expression studies.
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| |
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| Contributor(s) |
Rosenberg MJ, Wolff CR, El-Emawy A, Staples MC, Perrone-Bizzozero NI, Savage DD |
| Citation(s) |
20053520 |
| Submission date |
Sep 18, 2009 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Daniel Savage |
| E-mail(s) |
dsavage@salud.unm.edu
|
| Phone |
505-272-8808
|
| Fax |
505-272-8082
|
| Organization name |
University of New Mexico
|
| Department |
Neurosciences
|
| Street address |
1University of New Mexico
|
| City |
Albuquerque |
| State/province |
NM |
| ZIP/Postal code |
87131 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
|
| Samples (7)
|
|
| Relations |
| BioProject |
PRJNA119467 |
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