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| Status |
Public on Aug 15, 2010 |
| Title |
Expression data in HeLa S3 cells transfected with control-, UAP56- or URH49-siRNA |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Nuclear export of mRNA is an essential process for eukaryotic gene expression. TREX complex couples the gene expression from transcription and splicing to mRNA export. Sub2, a core component of TREX complex in yeast is diversified to two closely related RNA helicases, UAP56 and URH49 in human.UAP56 and URH49 are required for bulk poly (A)+ RNA export but their target genes are quite different. In conclusion, UAP56 and URH49 have a different function in vivo despite the highly similarity.
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| Overall design |
Cytoplasmic RNA was prepared in HeLa cells transfected with control-, UAP56- and URH49-siRNA and analyzed by gene expression array.
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| Contributor(s) |
Yamazaki T, Yukinaga H, Ebisuya M, Nishida E, Masuda S |
| Citation(s) |
20573985 |
| Submission date |
Sep 18, 2009 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Seiji Masuda |
| E-mail(s) |
masuda@kais.kyoto-u.ac.jp
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| Phone |
81-75-753-6273
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| Fax |
81-75-753-6274
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| Organization name |
Kyoto university
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| Department |
Graduate School of Biostudies
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| Lab |
Laboratory of Molecular Biology of Bioresponse
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| Street address |
Kitashirakara oiwaketyo
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| City |
Kyoto |
| State/province |
Kyoto |
| ZIP/Postal code |
606-8502 |
| Country |
Japan |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA119529 |
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