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| Status |
Public on Jan 20, 2022 |
| Title |
Transcriptome analysis of young and old zebrafish ventricles |
| Organism |
Danio rerio |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The gradual decline of tissue functionality is the main reason why humans suffer from age-related diseases. The prevalence for cardiovascular diseases increases with increasing age. In order to prevent age-related cardiac diseases, it is of importance to understand the respective age-associated risk factors. We have therefore compared the ventricular transcriptome of old and young hearts of the model organism zebrafish. We identified the immune system as activated in the old and found muscle organization to deteriorate upon aging. We show an accumulation of immune cells, mostly macrophages, in the old zebrafish ventricle.
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| |
|
| Overall design |
6 samples: ventricle of 3 young and 3 old individuals
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| |
|
| Contributor(s) |
Groth M, Koch P, Reuter H, Englert C |
| Citation(s) |
35159152 |
| Submission date |
Aug 28, 2021 |
| Last update date |
Feb 28, 2022 |
| Contact name |
Philipp Koch |
| Organization name |
Leibniz Institute on Aging - Fritz Lipmann Institute
|
| Department |
Core Facility Life Science Computing
|
| Street address |
Beutenbergstraße 11
|
| City |
Jena |
| ZIP/Postal code |
07745 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL18413 |
Illumina HiSeq 2500 (Danio rerio) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA758577 |
| SRA |
SRP334564 |
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