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Series GSE18323 Query DataSets for GSE18323
Status Public on Sep 30, 2009
Title Expression data from a malaria vaccine trial (HG-U133A2.0 and U133 Plus 2.0)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Volunteers were assessed at study entry, the day of the third vaccination and 24, 72 hours, two weeks after vaccination, and 5 days after challenge. 13/39 vaccinees were protected and 26/39 were not protected. Eleven vaccinees exhibited delayed onset of parasitemia. All infectivity controls developed parasitemia. Prediction Analysis of Microarrays (PAM-R) identified genes corresponding with protection. Gene Set Enrichment Analysis (GSEA) identified sets of genes associated with protection after the third immunization, before challenge.
After the third immunization, prior to challenge, differential expression of genes in the immunoproteasome pathway distinguished protected and non protected persons
 
Overall design Samples were collected at study entry, the day of third vaccination, 24 and 72 hours post the third vaccination and two weeks post the third vaccination as well as 5 days post challenge. Both longitudinal and cross-sectional analysis were carried out to investigate expression profiles associated with vaccine effects and vaccine efficacy. This dataset contains 215 samples from HG-U133 A 2.0 platform and 39 samples from HG Plus2.0 platform.
 
Contributor(s) Vahey M
Citation(s) 20078211
Submission date Sep 29, 2009
Last update date Mar 25, 2019
Contact name Maryanne Vahey
E-mail(s) mvahey@hivresearch.org
Phone 301-251-5058
Fax 301-762-7460
Organization name Walter Reed Army Institute of Research
Department
Lab Laboratory of Functional Genomics
Street address 1600 East Gude Drive
City Rockville
State/province MD
ZIP/Postal code 20850
Country USA
 
Platforms (2)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (254)
GSM457370 volunteer V01 at time point T0
GSM457371 volunteer V01 at time point T3
GSM457372 volunteer V01 at time point T4
Relations
BioProject PRJNA117977

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE18323_RAW.tar 697.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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