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Series GSE183231 Query DataSets for GSE183231
Status Public on Sep 04, 2021
Title Identification of recurrence biomarkers in over 40 year’s women with lymph-node-positive primary breast cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Several studies provide genes expression characteristic correlated to recurrence in breast cancer patients with lymph node negative. However few reports mentioned about the gene expression file in patients with lymph node metastasis confirmed during surgery, of which the cumulative incidences of relapse are more than 50%.
 
Overall design A total of 37 patients were followed up for more than 5 years. Sections of formalin-fixed paraffin embedded (FFPE) were prepared from breast tumors and well preserved. Twenty-five FFPE samples of ductual breast cancer patients with recurrent cancer and 12 FFPE samples of ductal breast cancer patients with no recurrence were analyzed the gene expression difference. Cancer tissues with ER positive or negative status were determined by immunohistochemistry method. All patients had positive lymph nodes confirmed during surgery and accompanied with lymphocytic invasion. All patients began to take Tamoxifen medicine after surgery and continued for more than 5 years or until cancer recurrence. All patients in this analysis had received chemotherapy treatment.
 
Contributor(s) Ye L, Ma SS, Zhang F, Xu T, Ji Z, Liu E
Citation(s) 36927310
Submission date Sep 02, 2021
Last update date Jul 14, 2023
Contact name Enuo Liu
E-mail(s) liuenuo@sippr.org.cn
Organization name Shanghai Institute for Biomedical and Pharmaceutical Technologies
Street address 2140 Xietu Road
City Shanghai
ZIP/Postal code 200032
Country China
 
Platforms (1)
GPL23126 [Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version]
Samples (37)
GSM5553654 ER+recurrence, biological rep01
GSM5553655 ER+recurrence, biological rep02
GSM5553656 ER+recurrence, biological rep03
Relations
BioProject PRJNA759760

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Supplementary file Size Download File type/resource
GSE183231_RAW.tar 844.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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