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| Status |
Public on Sep 16, 2021 |
| Title |
Human placental exosomes induce maternal systemic immune tolerance in a monocyte-dependent manner |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Maternal immune tolerance toward to the semi-allograft fetus is a prerequisite condition for successful pregnancy. However, the role of maternal monocytes in the induction of systemic immune tolerance is poorly understood. Here we report that placenta facilitates maternal immune tolerance by extruding exosomes. Maternal monocytes were transformed into an immunosuppressive phenotype after taking up exosomes. Mechanistically, PD-L1 was significantly increased in pEXO-educated monocytes via miRNA-29a-3p/PTEN signaling pathway. In addition, pEXO-treated monocytes could increase Treg pool in maternal blood through a direct cell-cell interaction. Moreover, Th1 cytokines, IFNγ and TNF-α, in monocyte-T cell co-culture system were significantly decreased. Together, our results indicated that maternal monocyte is indispensable components in systemic immune tolerance establishment.
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| Overall design |
mRNA profiles of pEXO-treated monocyte (N=4) and Control monocyte (N=4)
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| Contributor(s) |
Chiu PC, Kunfeng B |
| Citation(s) |
35180876 |
| Submission date |
Sep 13, 2021 |
| Last update date |
Feb 28, 2022 |
| Contact name |
Jianlin Li |
| Organization name |
The university of Hong Kong
|
| Street address |
L 7-08, Department of Obstetrics and Gynecology Laboratory block, 21th Sassoon Road, Hong Kong
|
| City |
Hong Kong |
| ZIP/Postal code |
999077 |
| Country |
Hong Kong |
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| Platforms (1) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA762864 |
| SRA |
SRP336817 |
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