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| Status |
Public on Oct 05, 2009 |
| Title |
Expression data from Trk-overexpressing NB cell line SY5Y |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Neurotrophin receptors play a pivotal role in the biology and prognosis of neuroblastoma (NB). While expression of TrkA/NTRK1 confers a good prognosis to NB patients, expression of TrkB/NTRK2 is associated with unfavorable outcome. We have transfected the neurotrophin-receptor null cell line SY5Y with either full-length TrkA or TrkB and performed transcriptional profiling to analyse the effects of Trk-expression without activation and in a time course after activation.
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| Overall design |
SY5Y transfected with either full length TrkA- or TrkB cDNA or vector control were cultivated in the absence or presence of their ligands NGF and BDNF, respectively. At the indicated time points cells were harvested and analysed using Affymetrix U95Av2 chips.
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| Contributor(s) |
Schramm A, Schulte JH |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 05, 2009 |
| Last update date |
Dec 13, 2018 |
| Contact name |
Alexander Schramm |
| E-mail(s) |
alexander.schramm@uk-essen.de
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| Organization name |
University Hospital Essen
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| Department |
Childrens Hospital
|
| Lab |
Hematology/Oncology Lab
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| Street address |
Hufelandstr. 55
|
| City |
Essen |
| ZIP/Postal code |
45122 |
| Country |
Germany |
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| Platforms (1) |
| GPL8300 |
[HG_U95Av2] Affymetrix Human Genome U95 Version 2 Array |
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| Samples (28)
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| Relations |
| BioProject |
PRJNA118261 |
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