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| Status |
Public on Oct 08, 2021 |
| Title |
Su(H) ChIP-on-chip of Notch-stimulated overgrowing Drosophila melanogaster wing imaginal discs |
| Organism |
Drosophila melanogaster |
| Experiment type |
Genome binding/occupancy profiling by genome tiling array
|
| Summary |
Aim: Su(H) chromatin occupancy profiling by ChIP on larval wing imaginal discs of Drosophila melanogaster to study the cooperation between Notch activation and loss of epithelial polarity (scrib mutation) during neoplastic growth.
Results: The combination of Notch activation and scribble mutation (NS) does not lead to a general redeployment of Su(H) binding as compared to individual conditions (Notch only (N), and scrib mutation only (S))
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| Overall design |
Duplicates of pooled dissected 3rd instar larva wing imaginal discs. All dissections at day 6 after egg laying for the following conditions: activated Notch (N), polarity deficient (scrib1 mutant, S), activated Notch and polarity deficient (NS)
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| |
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| Contributor(s) |
Djiane A, Bray SJ, Logeay R, Fischer B |
| Citation(s) |
35005772 |
| Submission date |
Oct 07, 2021 |
| Last update date |
Feb 07, 2022 |
| Contact name |
Alexandre Djiane |
| E-mail(s) |
alexandre.djiane@inserm.fr
|
| Organization name |
Inserm
|
| Department |
IRCM
|
| Street address |
208 rue des apothicaires
|
| City |
Montpellier |
| ZIP/Postal code |
34298 |
| Country |
France |
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| Platforms (1) |
| GPL15057 |
NimbleGen Drosophila melanogaster Whole Genome 2.1M tiling array [DM_5_Catalog_tiling_HX1; DesignID 6725] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA769269 |
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