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| Status |
Public on Oct 15, 2021 |
| Title |
An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer [h3k27ac] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant properties require further elucidation to galvanize translational advances. We therefore aimed to characterize a key factor that blocks intestinal differentiation, define its transcriptional and epigenetic program, and provide preclinical evidence for therapeutic targeting in CRC.
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| |
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| Overall design |
Examination of 5 different H3K27Ac experiments with two replicates each. M303 refers to a truncated version of SOX9.
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| |
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| Contributor(s) |
Liang X, Duronio GN, Yang Y, Bala P, Hebbar P, Spisak S, Sahgal P, Singh H, Zhang Y, Xie Y, Cejas P, Long HW, Bass AJ, Sethi NS |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 12, 2021 |
| Last update date |
Oct 19, 2021 |
| Contact name |
Nilay S Sethi |
| E-mail(s) |
Nilay_sethi@dfci.harvard.edu
|
| Organization name |
Dana Farber Cancer Institute
|
| Department |
Department of Medical Oncology
|
| Lab |
​Gastrointestinal Cancer Research
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| Street address |
450 Brookline Ave
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (10)
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| This SubSeries is part of SuperSeries: |
| GSE185747 |
An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer |
|
| Relations |
| BioProject |
PRJNA770645 |
| SRA |
SRP341026 |
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