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| Status |
Public on Nov 01, 2021 |
| Title |
Downregulation of HDAC9 by β-hydroxybutyrate suppresses vascular calcification in chronic kidney disease |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In this study, we report the protective effect of β-hydroxybutyrate (BHB) on vascular calcification in chronic kidney disease (CKD). To further investigate the mechanism underpinning the protective effect of BHB on vascular calcification, we performed high-throughput RNA-seq to identify the target gene of BHB. Our data demonstrate that BHB supplementation inhibits vascular calcification in CKD via targeting HDAC9.
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| Overall design |
Human vascular smooth muscle cells were cultured in calcifying medium (CM) in the presence or absence of β-hydroxybutyrate (BHB). RNA-seq was performed to determine the downstream target of BHB.
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| Contributor(s) |
Yan J, Lan Z |
| Citation(s) |
35894849 |
| Submission date |
Oct 28, 2021 |
| Last update date |
Aug 12, 2022 |
| Contact name |
Zirong Lan |
| E-mail(s) |
lanzirongwork@126.com
|
| Organization name |
Zhujiang Hospital, Southern Medical University
|
| Street address |
253 Industrial Avenue
|
| City |
Guangzhou |
| ZIP/Postal code |
510280 |
| Country |
China |
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| Platforms (1) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA775999 |
| SRA |
SRP343652 |
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