|
| Status |
Public on Dec 07, 2009 |
| Title |
Myeloid progenitor cells lacking p53 exhibit delayed upregulation of Puma, prolonged survival after cytokine deprivation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We generated WT and p53-/- Factor Dependent Myeloid (FDM) cells and found that p53-/- cells were protected against IL-3 withdrawal. A survival advantage was also observed in untransformed p53-/- hematopoietic progenitor cells cultured in the presence or absence of cytokines. Array analysis was perfomed on RNA extracted from WT and p53-/- FDM cells.
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| |
|
| Overall design |
Total RNA obtained from WT and p53-/- FDM cells cultured in the presence or absence of IL-3
|
| |
|
| Contributor(s) |
Jabbour AM, Ekert PG, Gordon LC |
| Citation(s) |
22348085 |
| Submission date |
Oct 27, 2009 |
| Last update date |
Aug 27, 2019 |
| Contact name |
Anissa Jabbour |
| E-mail(s) |
jabbour@wehi.edu.au
|
| Organization name |
Walter and Eliza Hall Institute
|
| Department |
Cell Signalling and Cell Death
|
| Lab |
Cell Biology Laboratory
|
| Street address |
1G Royal Parade
|
| City |
Parkville |
| State/province |
Victoria |
| ZIP/Postal code |
3052 |
| Country |
Australia |
| |
|
| Platforms (1) |
| GPL6105 |
Illumina mouse-6 v1.1 expression beadchip |
|
| Samples (18)
|
| GSM465848 |
Mouse_-il-3 replicate 1 time 6hrs |
| GSM465849 |
Mouse_-il-3 replicate 2 time 6hrs |
| GSM465850 |
Mouse_-il-3 replicate 3 time 6hrs |
| GSM465851 |
Mouse_-il-3 replicate 1 time 18hrs |
| GSM465852 |
Mouse_-il-3 replicate 2 time 18hrs |
| GSM465853 |
Mouse_-il-3 replicate 3 time 18hrs |
| GSM465854 |
Mouse_+il-3 replicate 1 p53-/- time 0 |
| GSM465855 |
Mouse_+il-3 replicate 2 p53-/- time 0 |
| GSM465856 |
Mouse_+il-3 replicate 3 p53-/- time 0 |
| GSM465857 |
Mouse_-il-3 replicate 1 p53-/- time 6hrs |
| GSM465858 |
Mouse_-il-3 replicate 2 p53-/- time 6hrs |
| GSM465859 |
Mouse_-il-3 replicate 3 p53-/- time 6hrs |
| GSM465860 |
Mouse_-il-3 replicate 1 p53-/- time 18hrs |
| GSM465861 |
Mouse_-il-3 replicate 2 p53-/- time 18hrs |
| GSM465862 |
Mouse_-il-3 replicate 3 p53-/- time 18hrs |
|
| Relations |
| BioProject |
PRJNA121619 |
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