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| Status |
Public on Nov 15, 2021 |
| Title |
The Schistosoma mansoni nuclear receptor FTZ-F1 maintains esophageal gland function via direct transcriptional regulation of meg-8.3 |
| Organism |
Schistosoma mansoni |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The schistosome homolog of ftz-f1 is a nuclear receptor. In order to understand the function of Smftz-f1, we performed RNAseq with samples taken on two days, Day 5 and Day 9, on either control (RNAi) or Smftz-f1 (RNAi) parasites to see the transcriptional consequences of Smftz-f1 RNAi and to find potential transcriptional targets.
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| Overall design |
Adult male parasites were treated with either control dsRNA or Smftz-f1-targeting dsRNA and taken at two different time points (Day 5 and Day 9), then subjected to RNAseq.
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| |
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| Contributor(s) |
Romero AA, Mangelsdorf DJ, Collins JJ |
| Citation(s) |
34910770 |
| Submission date |
Nov 12, 2021 |
| Last update date |
May 05, 2022 |
| Contact name |
George Wendt |
| E-mail(s) |
George.Wendt@UTSouthwestern.edu
|
| Organization name |
University of Texas Southwestern Medical Center
|
| Department |
Pharmacology
|
| Lab |
Collins
|
| Street address |
6001 Forest Park Road, ND7.300
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390 |
| Country |
USA |
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| Platforms (1) |
| GPL28252 |
NextSeq 550 (Schistosoma mansoni) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA780015 |
| SRA |
SRP345879 |
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