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Series GSE189357 Query DataSets for GSE189357
Status Public on Nov 30, 2021
Title Spatiotemporal transcriptional atlas of lung adenocarcinoma from adenocarcinoma in situ to invasive carcinoma [scRNA-seq]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary To illuminate the evolutionary trajectory of LUAD from AIS to IAC, high-throughput scRNA-seq and ST data were generated and integrated to create a large-scale, single-cell spatiotemporal atlas of LUAD. We compiled a multi-omics atlas of the early-stage LUAD invasion process that reflects the heterogeneity of cancer cells, the competitive polyclonal origin of LUAD, signalling interactions between cancer cells and the TME, and the pseudo-chronological nature of LUAD invasion. The spatial distribution characteristics of LUAD cells revealed the spatial heterogeneity of LUAD and the mechanism of spatial immune escape in LUAD, which provides strong evidence supporting clinical diagnosis and surgical intervention at the single-cell level.
Overall design Nine resected samples (TD1-9, three each from AIS, MIA and IAC cases) from nine treatment-naïve patients were collected for droplet-based scRNA-seq. In parallel, six paired samples were subjected to ST
Contributor(s) Jiang T, Sun S, Fan Y, Zhu J
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Submission date Nov 22, 2021
Last update date Dec 02, 2021
Contact name Yue Fan
Organization name Xi'an Jiaotong University
Street address Yanta West Road No.76
City Xi'an
ZIP/Postal code 710061
Country China
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (9)
GSM5699777 TD1 scRNA-seq
GSM5699778 TD2 scRNA-seq
GSM5699779 TD3 scRNA-seq
BioProject PRJNA782639
SRA SRP347260

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE189357_RAW.tar 623.9 Mb (http)(custom) TAR (of MTX, TSV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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