|
| Status |
Public on Nov 30, 2021 |
| Title |
Mitochondrial Plasticity Promotes Resistance to Sorafenib and Vulnerability to STAT3 Inhibition in Human Hepatocellular Carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Enhanced expression of mitochondrial ribosomal proteins and marked reprogramming of the mitochondrial network are associated with sorafenib resistance in human cell lines and hepatocarcinoma patients, providing novel actionable targets for increasing therapeutic efficacy.
|
| |
|
| Overall design |
Comparison between 2 conditions (3 replicates for each condition)
|
| |
|
| Contributor(s) |
Sandrini G, Catapano CV |
| Citation(s) |
34885140 |
| Submission date |
Nov 28, 2021 |
| Last update date |
Dec 15, 2021 |
| Contact name |
Giada Sandrini |
| E-mail(s) |
giada.sandrini@ior.usi.ch
|
| Organization name |
IOR
|
| Street address |
Via Chiesa 5
|
| City |
Bellinzona |
| ZIP/Postal code |
6500 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA784262 |
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