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Series GSE19122 Query DataSets for GSE19122
Status Public on Jan 30, 2010
Title Transcriptomic Comparison in the Retinas of Two Mouse Models of Diabetes
Organism Mus musculus
Experiment type Expression profiling by array
Summary Mouse models of type I diabetes offer the potential to combine genetic approaches with other pharmacological or physiological manipulations to investigate the pathophysiology and treatment of diabetic retinopathy. Type I diabetes is induced in mice through chemical toxins or may arise spontaneously from genetic mutations. Both models are associated with retinal vascular and neuronal changes. Retinal transcriptomic responses in C57BL/6J mice treated with strepotozotocin and Ins2Akita were compared after 3 months of hyperglycemia. Specific gene expression changes suggest a neurovascular inflammatory response in diabetic retinopathy. Genes common to the two models may represent the response of the retina to hyperglycemia; while changes unique to each model may represent time-dependent disease progression differences in the various models. Further investigation of the commonalities and differences between mouse models of type I diabetes may define cause and effect events in early diabetic retinopathy disease progression.
 
Overall design To compare two mouse models of type I diabetes, ie, STZ-induced and Ins2Akita, a gene expression analysis was conducted examining whole retinas collected after 3 months of hyperglycemia.
 
Contributor(s) Freeman WM, Bixler GV, Brucklacher RM, Walsh E, Kimball SR, Jefferson LS, Bronson SK
Citation(s) 20157355
Submission date Nov 20, 2009
Last update date Jun 14, 2018
Contact name Penn State COM
Organization name Penn State College of Medicine
Department Genome Sciences Facility
Street address 500 University Drive
City Hershey
State/province PA
ZIP/Postal code 17033
Country USA
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (31)
GSM474283 WT1
GSM474284 WT2
GSM474285 WT3
Relations
BioProject PRJNA120735

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE19122_RAW.tar 3.1 Mb (http)(custom) TAR
GSE19122_non-normalized.txt.gz 5.0 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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