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| Status |
Public on Jul 07, 2010 |
| Title |
Expression data from TKI258 treated 4T1 tumors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
4T1 mouse mammary carcinoma cells have an autocrine FGFR active loop leading to constitutive activation of downstream signaling pathways. We found that FGFR inhibitors have a strong effect on 4T1 tumors in-vivo.
We used microarray to understand the contribution of FGFR signaling to the tumor formation upon TKI258 treatment.
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| Overall design |
4T1 cells were injected in the 4th mammary gland of Balb/C mice. After 7 days, daily treatment with TKI258 or water was performed for 14 days. At the end of the experiment, the RNA were extracted from three individual tumors per condition and hybridized on Affimetrix microarrays.
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| Contributor(s) |
Dey JH, Oakeley EJ |
| Citation(s) |
20460524 |
| Submission date |
Nov 30, 2009 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Julien Herve Dey |
| Organization name |
FMI
|
| Department |
growth control
|
| Lab |
Hynes
|
| Street address |
Maulbeerstrasse
|
| City |
Basel |
| ZIP/Postal code |
4058 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| GSM476153 |
4T1 tumor treated with water, biological replicate 1 |
| GSM476154 |
4T1 tumor treated with water, biological replicate 2 |
| GSM476155 |
4T1 tumor treated with water, biological replicate 3 |
| GSM476156 |
4T1 tumor treated with TKI258, biological replicate 1 |
| GSM476157 |
4T1 tumor treated with TKI258, biological replicate 2 |
| GSM476158 |
4T1 tumor treated with TKI258, biological replicate 3 |
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| This SubSeries is part of SuperSeries: |
| GSE19222 |
Expression data from TKI258 treated 4T1 cells and 4T1 tumors |
|
| Relations |
| BioProject |
PRJNA123679 |
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