|
| Status |
Public on Jun 30, 2010 |
| Title |
Gene expression changes in multiple sclerosis relapse suggest activation of T and non-T cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
paired comparison of RNA expression in peripheral blood mononuclear cells in the same group of 14 multiple sclerosis patients while stable and while in relapse.
A defining feature of multiple sclerosis is the occurrence of clinical relapses separated by periods of clinical stability. Better understanding of the events underlying clinical relapse might suggest new approaches to treatment. We used microarrays to measure mRNA expression in the peripheral blood of 14 MS patients during clinical relapse and while stable. Seventy-one transcripts changed expression at the p<0.001 significance level. The most notable finding was decreased expression of transcripts with regulatory function, expressed primarily in non-T cells. Transcripts with increased expression were primarily expressed in T cells. Pathways analysis suggested involvement of the cytokine network, coagulation and complement cascades, IL-10 signaling, and NF-?B signaling.
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| |
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| Overall design |
total RNA from PBMC in relapse and while stable from 14 multiple sclerosis patients
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| |
|
| Contributor(s) |
Lindsey JW |
| Citation(s) |
20882258 |
| Submission date |
Nov 30, 2009 |
| Last update date |
Mar 20, 2017 |
| Contact name |
John William Lindsey |
| E-mail(s) |
john.w.lindsey@uth.tmc.edu
|
| Phone |
713 500 7141
|
| Fax |
713 500 7040
|
| Organization name |
University of Texas Health Science Center at Houston
|
| Department |
Neurology
|
| Street address |
6431 Fannin, Suite 7.044
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6883 |
Illumina HumanRef-8 v3.0 expression beadchip |
|
| Samples (28)
|
|
| Relations |
| BioProject |
PRJNA120847 |
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