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Series GSE193128 Query DataSets for GSE193128
Status Public on Jan 10, 2022
Title Skin expression data from psoriasis patients treated with the HSP90 inhibitor RGRN-305
Organism Homo sapiens
Experiment type Expression profiling by array
Summary HSP90 is a downstream regulator of TNFα and IL-17A signaling and may therefore serve as a novel target in the treatment of psoriasis.
We assessed global gene expression by microarray analysis to explore the molecular transformation in skin samples from psoriatic patients during treatment with the HSP90 inhibitor RGRN-305.
 
Overall design Skin punch biopsies were taken from nonlesional (NL) and lesional (LS) psoriatic skin of 13 psoriatic patients before treatment and from lesional psoriatic skin at 4, 8, and 12 weeks during HSP90 inhibitor treatment. RNA was extracted from the skin biopsies and used for microarray analysis.
 
Contributor(s) Litman T, Johansen C, Bregnehøj A, Emmanuel T, Iversen L
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Submission date Jan 06, 2022
Last update date Jan 12, 2022
Contact name Thomas Litman
E-mail(s) tlitman@hotmail.com
Phone 4541851753
Organization name University of Copenhagen
Department ISIM
Street address Blegdamsvej 3C
City Copenhagen N
State/province Outside the US or Canada
ZIP/Postal code 2200
Country Denmark
 
Platforms (1)
GPL23126 [Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version]
Samples (61)
GSM5773787 Patient 01 non-lesional skin week 0
GSM5773788 Patient 01 lesional skin week 0
GSM5773789 Patient 01 lesional skin week 4
Relations
BioProject PRJNA795043

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE193128_RAW.tar 1.6 Gb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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