|
| Status |
Public on Aug 11, 2011 |
| Title |
Sarcoidosis-specific markers from whole blood gene expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We hypothesized that microarray analyses of whole blood gene expression would identify patterns of gene expression useful in the diagnosis for sacroidosis and identify inflammatory mediators relevant to the underlying pathophysiology.
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| |
|
| Overall design |
We analyzed whole blood RNA from 37 patients with sarcoidosis, 20 healthy controls and 6 patients with hypersensitivity pneumonitis using genome-wide expression microarrays. We developed a classification algorithm using a derivation and validation subset approach, analyzed the most discriminative gene expression changes, and confirmed selected expression changes using flow-cytometry.
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| |
|
| Contributor(s) |
Woodruff PG, Koth LL |
| Citation(s) |
21852540, 25142485 |
| Submission date |
Dec 03, 2009 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Prescott Gurney Woodruff |
| E-mail(s) |
prescott.woodruff@ucsf.edu
|
| Phone |
4155142061
|
| Fax |
4154765712
|
| Organization name |
UCSF
|
| Department |
Medicine
|
| Lab |
Woodruff Lab
|
| Street address |
505 Parnassus Ave
|
| City |
San Francisco |
| State/province |
CA |
| ZIP/Postal code |
94143 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (66)
|
|
| Relations |
| BioProject |
PRJNA120911 |
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