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| Status |
Public on Sep 05, 2010 |
| Title |
Expression data of primary melanocytes from aryl hydrocarbon deficient mice and corresponding wild-type C57BL/6 mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
[original Title] Comparison of expression data of primary murine melanocytes from aryl hydrocarbon deficient mice and corresponding wild-type C57BL/6 mice
Melanin is produced exclusively by melanocytes and melanogenesis is the vital response to protect skin cells against Ultraviolet B (UVB)-induced DNA damage. The aryl hydrocarbon receptor (AhR) is a transcription factor, which may be involved in the physiological tanning response. Normal murine melanocytes express functional AhR. We tested gene expression in WT versus AhR-deficient mice primary murine melanocytes, isolated from the skin and cultivated for several passages.
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| Overall design |
Skin epidermal cells from 2 individual C57BL/6 mice and 2 individual AhR-deficient mice (deletion of exon2, AhRtm1Bra) were grown for 6-8 weeks in selection medium to propagate melanocytes.
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| Contributor(s) |
Esser C, Jux B |
| Citation(s) |
20861855, 20973933 |
| Submission date |
Dec 10, 2009 |
| Last update date |
May 04, 2018 |
| Contact name |
Charlotte Esser |
| E-mail(s) |
chesser@uni-duesseldorf.de
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| Organization name |
IUF
|
| Department |
Molecular Immunology
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| Street address |
Auf´m Hennekamp 50
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| City |
Dusseldorf |
| ZIP/Postal code |
40225 |
| Country |
Germany |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA121785 |
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