|
| Status |
Public on May 01, 2011 |
| Title |
Coxsackievirus B3 (CVB3) infection of AJ, B10.A, CSS3 and B6.chr3AJ (heart tissue day 4) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The pathogenesis of viral myocarditis is a multifactorial process involving host genetics, viral genetics and the environment in which they interact. Here, we used a model of infection with Coxsackievirus B3 to characterize the contribution of host genetics to viral myocarditis. We determined heart CVB3 load in mice from a classical intercross between progenitors A/J (H2a) and B10.A-H2a (B10.A) of different genetic backgrounds but with a common H2 haplotype. Here we compare whole genome expression patterns in infected and uninfected A/J and B10.A mice in order to determine which gene expression programs are common or distinct to each strain.
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| |
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| Overall design |
Total RNA obtained from hearts of 3 AJ, 3 B10.A(H2a), 3 CSS3 and 3 B6.chr3AJ that were infected or uninfected with CVB3(CG) at 400pfu/g and collected at day 4 post infection.
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| |
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| Contributor(s) |
Vidal S, Wiltshire S |
| Citation(s) |
21525387 |
| Submission date |
Dec 15, 2009 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Sean A Wiltshire |
| Organization name |
McGill University
|
| Department |
Human Genetics
|
| Lab |
Silvia Vidal
|
| Street address |
3649 Sir william Osler, Rm 356
|
| City |
Montreal |
| ZIP/Postal code |
H3G 0B1 |
| Country |
Canada |
| |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
|
| Samples (24)
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| Relations |
| BioProject |
PRJNA122413 |
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