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| Status |
Public on Jun 04, 2010 |
| Title |
Temporal dysregulation of cortical gene expresssion in the isolation-reared Wistar rat |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
The critical sequence of molecular, neurotransmission and synaptic disruptions that underpin the emergence of psychiatric disorders like schizophrenia remain to be established with progress only likely using animal models that capture key features of such disorders.
Gene expression was assessed in social control and isolation reared rats at 4 increasing postnatal ages to relate gene expression dysregulation to behavioural and endophenotype emergence.
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| Overall design |
We prepared cDNA from brain tissue samples of the medial prefrontal cortex from socially reared Wistar rats (Soc) and matching isolation reared cohorts (Iso) at postnatal day (P) 30, 40, 60 and 80.
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| Contributor(s) |
Murphy KJ, von Schack D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 24, 2009 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Keith J Murphy |
| E-mail(s) |
keith.murphy@ucd.ie
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| Organization name |
University College Dublin
|
| Department |
School of Biomolecular and Biomedical Science
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| Lab |
Applied Neurotherapeutics Research Group
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| Street address |
UCD Conway Institute, Belfield
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| City |
Dublin |
| ZIP/Postal code |
Dublin4 |
| Country |
Ireland |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (47)
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| Relations |
| BioProject |
PRJNA122551 |
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