|
| Status |
Public on Feb 15, 2022 |
| Title |
Small Extracellular Vesicles Secreted by Brown Adipose Tissue Mediate Exercise Cardioprotection via MicroRNA-Dependent Suppression of the MAPK Pathway |
| Organism |
Mus musculus |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
Long-term exercise provides reliable cardioprotection via incompletely understood mechanisms.The sEVs secreted by BAT participate in exercise cardioprotection via delivering the cardioprotective miRNAs into the heart. These results provide novel insights into the mechanisms underlying the BAT-cardiomyocyte interaction and highlight BAT sEVs and their contained miRNAs as alternative candidates for exercise cardioprotection.
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| |
|
| Overall design |
miRNA-Seq of BAT sEVs and plasma sEVs before and after exercise in mice
|
| |
|
| Contributor(s) |
Tao L, Zhao H, Zhang F, Chen X |
| Citation missing |
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| Submission date |
Feb 14, 2022 |
| Last update date |
Feb 16, 2022 |
| Contact name |
Hang Zhao |
| E-mail(s) |
lingtao@fmmu.edu.cn
|
| Organization name |
Air force military medical university
|
| Street address |
127 Changle west road, Xi 'an China
|
| City |
Xi 'an |
| ZIP/Postal code |
710032 |
| Country |
China |
| |
|
| Platforms (1) |
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| Samples (10)
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|
| Relations |
| BioProject |
PRJNA806775 |
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