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Series GSE19873 Query DataSets for GSE19873
Status Public on Jan 14, 2010
Title Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction.
Organism Mus musculus
Experiment type Expression profiling by array
Summary To identify genes expressed during initiation of lung organogenesis, we generated transcriptional profiles of the prospective lung region of the mouse foregut (mid-foregut) microdissected from embryos at three developmental stages between embryonic day 8.5 (E8.5) and E9.5. This period spans from lung specification of foregut cells to the emergence of the primary lung buds. We identified a number of known and novel genes that are temporally regulated as the lung bud forms. Genes that regulate transcription, including DNA binding factors, co-factors, and chromatin remodeling genes, are the main functional groups that change during lung bud formation. Members of key developmental transcription and growth factor families, not previously described to participate in lung organogenesis, are expressed in the mid-foregut during lung bud induction. These studies also show early expression in the mid-foregut of genes that participate in later stages of lung development. This characterization of the mid-foregut transcriptome provides new insights into molecular events leading to lung organogenesis.
 
Overall design Three samples (developmental stages), three biological replicates (5-10 pooled mid-foreguts)
 
Contributor(s) Millien G, Beane J, Lenburg M, Tsao P, Lu J, Spira A, Ramirez MI
Citation(s) 18023262
Submission date Jan 13, 2010
Last update date Jan 08, 2019
Contact name Maria Isabel Ramirez
E-mail(s) mramirez@bu.edu
Organization name Boston University School of Medicine
Department Medicine
Lab Pulmonary Center
Street address 72 E. Concord St. E603
City Boston
State/province MA
ZIP/Postal code 02118
Country USA
 
Platforms (1)
GPL339 [MOE430A] Affymetrix Mouse Expression 430A Array
Samples (9)
GSM496702 16-20 somites mid-foregut, biological rep1
GSM496703 16-20 somites mid-foregut, biological rep2
GSM496704 16-20 somites mid-foregut, biological rep3
Relations
BioProject PRJNA121967

Download family Format
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE19873_RAW.tar 21.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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