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| Status |
Public on Dec 01, 2010 |
| Title |
Effect of valproic acid on hematopoiesis: A functional profiling and cell phenotyping approach |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Analysis of the effects of valproic acid (VPA) on chronic myelogenous leukemia K562 cells. This study attempts to elucidate the effects of VPA on cell homeostasis and hematopoietic differentiation pathways in this cell line.
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| Overall design |
We used ten experimental conditions comparing valproic acid-treated and untreated cells at time points 2, 6, 10, 48 and 72 hrs respectively. Experiments were performed in three biological replicates including a dye swap (represented by replicate 3, for each timepoint).
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| Contributor(s) |
Chateauvieux S, Eifes S, Morceau F, Schnekenburger M, Grigorakaki C, Henry E, Dicato M, Diederich M |
| Citation(s) |
21108933 |
| Submission date |
Jan 19, 2010 |
| Last update date |
Feb 22, 2018 |
| Contact name |
Marc Diederich |
| E-mail(s) |
marcdiederich@snu.ac.kr
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| Organization name |
Seoul National University
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| Department |
College of Pharmacy
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| Lab |
Molecular Oncology
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| Street address |
Gwanak-ro, Gwanak-gu, 1
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| City |
Seoul |
| ZIP/Postal code |
08826 |
| Country |
South Korea |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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| Samples (15)
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| GSM498228 |
Valproic acid-treated cells vs. untreated cells at time point 2 hrs, replicate 1 |
| GSM498229 |
Valproic acid-treated cells vs. untreated cells at time point 2 hrs, replicate 2 |
| GSM498230 |
Valproic acid-treated cells vs. untreated cells at time point 2 hrs, replicate 3 |
| GSM498231 |
Valproic acid-treated cells vs. untreated cells at time point 6 hrs, replicate 1 |
| GSM498232 |
Valproic acid-treated cells vs. untreated cells at time point 6 hrs, replicate 2 |
| GSM498233 |
Valproic acid-treated cells vs. untreated cells at time point 6 hrs, replicate 3 |
| GSM498234 |
Valproic acid-treated cells vs. untreated cells at time point 10 hrs, replicate 1 |
| GSM498235 |
Valproic acid-treated cells vs. untreated cells at time point 10 hrs, replicate 2 |
| GSM498236 |
Valproic acid-treated cells vs. untreated cells at time point 10 hrs, replicate 3 |
| GSM498237 |
Valproic acid-treated cells vs. untreated cells at time point 48 hrs, replicate 1 |
| GSM498238 |
Valproic acid-treated cells vs. untreated cells at time point 48 hrs, replicate 2 |
| GSM498239 |
Valproic acid-treated cells vs. untreated cells at time point 48 hrs, replicate 3 |
| GSM498240 |
Valproic acid-treated cells vs. untreated cells at time point 72 hrs, replicate 1 |
| GSM498241 |
Valproic acid-treated cells vs. untreated cells at time point 72 hrs, replicate 2 |
| GSM498242 |
Valproic acid-treated cells vs. untreated cells at time point 72 hrs, replicate 3 |
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| Relations |
| BioProject |
PRJNA122631 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE19939_RAW.tar |
101.8 Mb |
(http)(custom) |
TAR (of GPR) |
| Processed data included within Sample table |
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