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Series GSE19961 Query DataSets for GSE19961
Status Public on Feb 15, 2010
Title Gene Expression Profile in kidneys from Cldn16 +/+, +/-, -/- female mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary Claudin-16 deficiency leads to renal salt wasting in humans and mice. Analysis of renal gene expression in Claudin-16 deficient mice, compared to heterozygous and wild type littermates, was performed to gain insights into molecular mechanisms compensating salt loss. Our results indicate the upregulation of known and putative genes for renal transcellular transporters. Furthermore, we could identify a transcript so far not associated with renal salt metabolism, which will provide a first link to a human electrolyte disorder disease.
 
Overall design Female Cldn16 +/+, +/-, -/- mice were sacrificed at the age of 8 weeks for kidney dissection, removal of kidney poles and preparation of total RNA for expression analysis.
 
Contributor(s) Müller D, Will C, Stuiver M
Citation(s) 20147368
Submission date Jan 20, 2010
Last update date Jan 16, 2019
Contact name Constanze Will
Organization name Charité
Department CCR
Street address Hessische Str. 3 - 4
City Berlin
ZIP/Postal code 10115
Country Germany
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (11)
GSM498687 Mouse No Cldn16 B9 439
GSM498688 Mouse No Cldn16 B9 442
GSM498689 Mouse No Cldn16 B9 450
Relations
BioProject PRJNA122609

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE19961_RAW.tar 15.8 Mb (http)(custom) TAR
GSE19961_raw_data.txt.gz 3.4 Mb (ftp)(http) TXT
Processed data included within Sample table
Raw data are available on Series record
Raw data provided as supplementary file

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