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| Status |
Public on Apr 30, 2010 |
| Title |
Mouse Lung Response to Stainless Steel and Mild Steel Welding Fume |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
A/J mice are genetically predisposed to spontaneous and/or chemically-induced lung tumors while C57BL/6J (B6) mice are resistant. This genetic disparity provides a unique scenario to identify molecular mechanisms associated with the lung response to welding fume at the transcriptome level.
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| Overall design |
Four mice per group were exposed four times by pharyngeal aspiration to 5mg/kg mild steel (MS) fume, stainless steel (SS) fume, or saline vehicle and were necropsied 28 days and 16 weeks after the last exposure. Whole lung microarray using Illumina Mouse Ref-8 version 1.1 expression beadchips was done.
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| Contributor(s) |
Zeidler-Erdely PC |
| Citation(s) |
20525249 |
| Submission date |
Feb 03, 2010 |
| Last update date |
Jan 18, 2013 |
| Contact name |
Patti Christine Zeidler-Erdely |
| E-mail(s) |
paz9@cdc.gov
|
| Phone |
3042855881
|
| Organization name |
CDC/NIOSH
|
| Department |
HELD
|
| Street address |
1095 Willowdale Road
|
| City |
Morgantown |
| State/province |
WV |
| ZIP/Postal code |
26505 |
| Country |
USA |
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| Platforms (1) |
| GPL6103 |
Illumina mouseRef-8 v1.1 expression beadchip |
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| Samples (48)
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| Relations |
| BioProject |
PRJNA125641 |
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