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Status |
Public on Oct 08, 2010 |
Title |
Interleukin-16-knock-out bone-marrow derived macrophages response to the Whipple's disease agent, Tropheryma whipplei |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
We have employed whole genome microarray expression profiling to identify differently expressed genes following infection of interleukin-16-knock-out bone-marrow derived macrophages with T. whipplei. Macrophages were infected with T. whipplei (MOI 50:1) for 6 hours and a signature was identified that distinguished between infected and control samples. Expression of several genes from this signature was quantified in the same RNA samples by real-time PCR, confirming the predicted macrophage response pattern.
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Overall design |
Gene expression in macrophages was measured at 6 hours after stimulation Three independent experiments were performed.
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Contributor(s) |
Desnues B, Mège J |
Citation(s) |
21042409 |
Submission date |
Feb 05, 2010 |
Last update date |
May 10, 2018 |
Contact name |
Benoit Desnues |
E-mail(s) |
benoit.desnues@univmed.fr
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Organization name |
Faculté de Médecine de la Timone
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Department |
URMITE UMR CNRS 6236
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Street address |
27 boulevard Jean Moulin
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City |
Marseille |
ZIP/Postal code |
13385 cedex 05 |
Country |
France |
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Platforms (1) |
GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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Samples (6)
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This SubSeries is part of SuperSeries: |
GSE20210 |
Role of interleukin-16 in macrophage responses to Tropheryma whipplei and lipopolysaccharide |
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Relations |
BioProject |
PRJNA129803 |