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| Status |
Public on Nov 09, 2022 |
| Title |
BRD4 inhibitor GNE987 exerts anti-cancer effects by targeting C-Myc and S100A16 in Glioblastoma [ChIP-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Glioblastoma (GBM) in children is a relatively more common primary central nervous system tumor with a high degree of malignancy, high mortality, and complex surgical complete resection.. GNE987 is a newly developed von Hippel-Lindau tumor suppressor (VHL)-based pan-BET-targeting PROTAC, which can bind to the target proteins (BET proteins, including BRD2, BRD3, and BRD4) and recruit them to the ubiquitin/ proteasome system for degradation. However, the function of GNE987 has not been assessed in GBM cells so far. In the present study, ChIP-Seq analysis was performed to explore the effect of GNE987 on GBM cells.
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| Overall design |
U87 cells were treated with control (DMSO) or GNE987 for 48h, and then harvested for chip with H3K27Ac antibody.
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| Contributor(s) |
Ma L, Li G |
| Citation(s) |
36224471 |
| Submission date |
May 08, 2022 |
| Last update date |
Nov 10, 2022 |
| Contact name |
Gen Li |
| E-mail(s) |
ligen925@yeah.net
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| Organization name |
Children's Hospital of Soochow University
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| Street address |
No. 92 Zhongnan Street
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| City |
Suzhou |
| State/province |
Jiangsu |
| ZIP/Postal code |
215025 |
| Country |
China |
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| Platforms (1) |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA836277 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE202484_RAW.tar |
414.9 Mb |
(http)(custom) |
TAR (of BW, NARROWPEAK) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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