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| Status |
Public on Jul 13, 2022 |
| Title |
A multi-omics investigation into the mechanisms of hyper-virulence in Mycobacterium tuberculosis |
| Organism |
Mycobacterium tuberculosis |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
The result validated the connections between mutations, gene expression and mycobacterial pathogenicity, and identified new possible virulence-associated pathways in M. tuberculosis.
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| Overall design |
We profiled the genome-wide expression pattern for hyper-virulent (H112) and low-virulent strains (H54) during exponential growth in a nutrient-rich condition (7H9 medium) and a physiologically relevant multi-stress condition (NR medium) using RNA-sequencing and label-free quantitative proteomics.
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| Contributor(s) |
RAJWANI R, GALATA C, SO P, LEUNG KS, TAM KK, SHEHZAD S, Ng TT, ZHU L, LEE AW, LAO HY, CHAN CT, LEUNG JS, LEE L, WONGd KC, YAM WC, SIU GK |
| Citation(s) |
35791449 |
| Submission date |
May 24, 2022 |
| Last update date |
Jul 13, 2022 |
| Contact name |
Wing Tung Lee |
| E-mail(s) |
annie1993118qq@hotmail.com
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| Organization name |
The Hong Kong Polytechnic University (PolyU)
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| Department |
Department of Health Technology and Informatics
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| Street address |
Room Y934, 9/F, Lee Shau Kee Building, The Hong Kong Polytechnic University, Hung Hom, Kowloon
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| City |
Hong Kong |
| ZIP/Postal code |
000 |
| Country |
Hong Kong |
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| Platforms (1) |
| GPL18768 |
Illumina HiSeq 2000 (Mycobacterium tuberculosis) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA841830 |
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