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| Status |
Public on Oct 12, 2010 |
| Title |
Regulation of Angiogenesis by EZH2 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
While VEGF-targeted therapies are showing promise in clinical studies, new angiogenesis targets are needed to make additional gains. Here, we show that increased Zeste homologue 2 (EZH2) expression in either tumor cells or in tumor vasculature is predictive of poor clinical outcome. The increase in endothelial EZH2 is a direct result of VEGF stimulation and indicates the presence of a paracrine circuit that promotes angiogenesis by methylating and silencing vasohibin 1 (VASH1). EZH2 silencing in the tumor-associated endothelial cells resulted in inhibition of angiogenesis mediated by reactivation of VASH1, and reduced ovarian cancer growth. Combined, these data provide a new understanding of the regulation of tumor angiogenesis and support the potential for targeting EZH2 as a novel therapeutic approach.
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| Overall design |
Pre-clinical study, DNA microarray (Illumina HumanHT-12)
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| Contributor(s) |
Mangala LS, Han H, Lu C, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena G, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MM, Lee J, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Guven EO, Chen Y, Li L, Hsu M, Coleman RL, Calin GA, Denkbas EB, Lim J, Lee J, Kundra V, Birrer MJ, Hung M, Lopez-Berestein G, Sood AK, Kim H |
| Citation(s) |
20708159 |
| Submission date |
Feb 17, 2010 |
| Last update date |
Aug 16, 2018 |
| Contact name |
Sangbae Kim |
| E-mail(s) |
sangbkim22@gmail.com
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| Organization name |
Baylor Colleage of Medicine
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| Department |
HGSC
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| Street address |
1 Baylor plaza
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA125505 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE20381_EZH2_raw_data.txt.gz |
2.5 Mb |
(ftp)(http) |
TXT |
| GSE20381_RAW.tar |
6.2 Mb |
(http)(custom) |
TAR |
| Processed data included within Sample table |
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