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Series GSE20407 Query DataSets for GSE20407
Status Public on Jul 01, 2010
Title Control of intestinal homeostasis, colitis and colitis-associated colorectal cancer by the inflammatory caspases
Organism Mus musculus
Experiment type Expression profiling by array
Summary Inflammatory caspases are essential effectors of inflammation and cell death. Here, we investigated their roles in colitis and colorectal cancer and report a bimodal regulation of intestinal homeostasis, inflammation and tumorigenesis by caspases-1 and -12. Casp1-/- mice exhibited defects in mucosal tissue repair and succumbed rapidly after dextran sulfate sodium (DSS) administration. This phenotype was rescued by administration of exogenous interleukin-18 and was partially reproduced in mice deficient in the inflammasome adaptor ASC. Casp12-/- mice, in which the inflammasome is derepressed, were resistant to acute colitis and showed signs of enhanced repair. Together with their increased inflammatory response, the enhanced repair response of Casp12-/- mice rendered them more susceptible to colorectal cancer induced by azoxymethane (AOM)+DSS. Taken together, our results indicate that the inflammatory caspases are critical in the induction of inflammation in the gut following injury, which is necessary for tissue repair and maintenance of immune tolerance.
Overall design Total RNA obtained from isolated tumors or normal colon tissue from wild type and caspase-12 deficient mice were compared.
Contributor(s) Yeretssian G, Saleh M
Citation(s) 20226691
Submission date Feb 18, 2010
Last update date Jun 14, 2018
Contact name Garabet Yeretssian
Organization name McGill
Department Medicine
Lab Saleh
Street address 3649 Promenade Sir-William Osler
City Montreal
State/province QC
ZIP/Postal code H3G 0B1
Country Canada
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (8)
GSM511199 WT-N1
GSM511200 WT-N2
GSM511201 C12-N1
BioProject PRJNA125543

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE20407_RAW.tar 3.1 Mb (http)(custom) TAR
GSE20407_matrix_non-normalized.txt.gz 1.3 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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