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Series GSE20423 Query DataSets for GSE20423
Status Public on Oct 02, 2010
Title Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice
Organism Mus musculus
Experiment type Expression profiling by array
Summary In order to explore the functions of carbonic anhydrase VI (CAVI) more fully, we examined the transcriptomic responses to CAVI deficiency in the submandibular gland, stomach, and duodenum of Car6-/- mice by cDNA microarray. 94, 56, and 127 genes were up- or down-regulated in the above-mentioned tissues of Car6-/- mice, respectively. The functional clustering of differentially expressed genes revealed a number of altered biological processes. In the duodenum, the significantly affected biological pathways included immune system process and retinol metabolic process. Response to oxidative stress and brown fat cell differentiation changed remarkably in the submandibular gland. Notably, the submandibular gland, stomach, and duodenum shared one prominent transcriptional susceptibility pathway-catabolic process.
 
Overall design Submandibular gland, stomach, and duodenum samples were collected from three wild-type and three Car6-/- female mice, respectively, at the age of two months. Total RNAs were purified and used for cDNA microarray.
 
Contributor(s) Pan P, Käyrä K, Leinonen J, Nissinen M, Parkkila S, Rajaniemi H
Citation(s) 20835760
Submission date Feb 19, 2010
Last update date Jun 14, 2018
Contact name Pei-wen Pan
Organization name Institute of Medical Technology, University of Tampere
Street address Biokatu 6
City Tampere
ZIP/Postal code 33520
Country Finland
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (18)
GSM512112 submandibular gland wild type rep1A
GSM512113 submandibular gland wild type rep2A
GSM512114 submandibular gland knockout rep1A
Relations
BioProject PRJNA125589

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE20423_RAW.tar 3.1 Mb (http)(custom) TAR
GSE20423_non-normalized.txt.gz 3.0 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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