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Series GSE20524 Query DataSets for GSE20524
Status Public on Feb 25, 2010
Title Blood Gene Expression Signatures Predict Invasive Candidiasis
Organism Mus musculus
Experiment type Expression profiling by array
Summary Focusing on host response to infection, we utilized a murine model to develop a  blood gene expression signature that accurately classified mice with candidemia and distinguished candidemia from S. aureus bacteremia.  Validation of the signature was achieved in an independent cohort of mice.
 
Overall design BALB/c male mice were injected with either normal saline, C.albicans, or S.aureus and sacrificed at pre-set time points of 24, 48, 72-96 hrs (Infection Duration). Blood was placed in RNA Later (R) for RNA expression analysis and the right kidney collected for analysis of pathogen burden.
 
Contributor(s) Zaas AK, Aziz H, Lucas J, Perfect JR, Ginsburg GS
Citation(s) 20374997
Submission date Feb 25, 2010
Last update date May 04, 2018
Contact name Hamza Aziz
E-mail(s) ha2@duke.edu
Organization name Duke University
Department Institute of Genomic Science and Policy
Lab Geoffrey Ginsburg
Street address 101 Science Drive
City Durham
State/province NC
ZIP/Postal code 27708
Country USA
 
Platforms (1)
GPL8321 [Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array
Samples (72)
GSM515522 C.albicans Initial Signature Cohort_1394_2828_14399_1000
GSM515523 C.albicans Initial Signature Cohort_1394_2828_14400_1001
GSM515524 C.albicans Initial Signature Cohort_1394_2828_14401_1002
Relations
BioProject PRJNA125135

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE20524_RAW.tar 122.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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