|
| Status |
Public on Feb 17, 2011 |
| Title |
MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
Non-coding RNA profiling by array
|
| Summary |
Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor due to activation of multiple cellular pathways and molecular alterations. Herein, we report the first molecular classification of 89 HCC based on the expression of 358 microRNAs and integrative genomic analysis. Three main subclasses of HCC were identified : two of them were associated with beta-catenin mutations or aggressive phenotype. A subset of the subclass of aggressive tumors (8/89, 9%) showed overexpression of a cluster of microRNAs located on chr19q13.41 (C19MC locus. We showed that miR 517a, representing C19MC, promoted cell proliferation, migration and invasion in vitro and induced the development of aggressive tumors in vivo suggesting its role as a novel oncogenic driver in HCC.
This SuperSeries is composed of the SubSeries listed below.
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| |
|
| Overall design |
Refer to individual Series
|
| |
|
| Citation(s) |
21324318, 22733778, 25826076 |
| Submission date |
Mar 02, 2010 |
| Last update date |
Jun 10, 2019 |
| Contact name |
Yujin Hoshida |
| E-mail(s) |
Yujin.Hoshida@UTSouthwestern.edu
|
| Organization name |
University of Texas Southwestern Medical Center
|
| Street address |
5323 Harry Hines Blvd
|
| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390 |
| Country |
USA |
| |
|
| Platforms (4)
|
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
| GPL8432 |
Illumina HumanRef-8 WG-DASL v3.0 |
| GPL10122 |
Homo sapiens microRNA profiling platform version 4 |
|
| Samples (350)
|
|
| This SuperSeries is composed of the following SubSeries:
|
| GSE9843 |
Gene expression profiling of 91 hepatocellular carcinomas with hepatitis C virus etiology |
| GSE19977 |
Gene-expression profiles of formalin-fixed, paraffin-embedded human hepatocellular carcinoma |
| GSE20594 |
microRNA profiling of human hepatocellular carcinoma |
| GSE20679 |
mRNA expression profile modified by microRNA mir-517a (MIR517A) in human hepatocellular carcinoma cell line |
|
| Relations |
| BioProject |
PRJNA124713 |
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