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| Status |
Public on Nov 19, 2010 |
| Title |
Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
MENX is a rat multiple endocrine neoplasia syndrome caused by a homozygous mutation of the Cdkn1b gene, encoding p27Kip1. Affected rats develop adrenomedullary hyperplasia which progresses to pheochromocytoma with time (incidence 100%), and to extra-adrenal pheochromocytoma (paraganglioma) (68%).
We here report that hyperplasia and tumor have similar gene expression profiles, suggesting an early determination of the tumorigenic signature. Overexpressed genes in rat adrenal lesions are especially enriched in development/differentiation-associated genes.
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| Overall design |
We performed gene expression microarray analysis of 8 adrenal hyperplasias and 4 pheochromocytomas, each compared with adrenomedullary tissue from wild-type, age-matched littermates.
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| Contributor(s) |
Molatore S, Irmler M, Beckers J, Pellegata N |
| Citation(s) |
20937862 |
| Submission date |
Mar 22, 2010 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Johannes Beckers |
| E-mail(s) |
johannes.beckers@helmholtz-munich.de
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| Organization name |
Helmholtz Zentrum Muenchen
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| Department |
Institute of Experimental Genetics
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| Street address |
Ingolstaedter Landstr. 1
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| City |
Neuherberg |
| ZIP/Postal code |
85764 |
| Country |
Germany |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (16)
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| GSM524894 |
Adrenal gland pheochromocytoma, biological replicate 01 |
| GSM524895 |
Adrenal gland pheochromocytoma, biological replicate 02 |
| GSM524896 |
Adrenal gland pheochromocytoma, biological replicate 03 |
| GSM524897 |
Adrenal gland pheochromocytoma, biological replicate 04 |
| GSM524898 |
Adrenal gland medulla pool, biological replicate 1 |
| GSM524899 |
Adrenal gland medulla pool, biological replicate 2 |
| GSM524900 |
Adrenal gland medullary hyperplasia, biological replicate 01 |
| GSM524901 |
Adrenal gland medullary hyperplasia, biological replicate 02 |
| GSM524902 |
Adrenal gland medullary hyperplasia, biological replicate 03 |
| GSM524903 |
Adrenal gland medullary hyperplasia, biological replicate 04 |
| GSM524904 |
Adrenal gland medullary hyperplasia, biological replicate 05 |
| GSM524905 |
Adrenal gland medullary hyperplasia, biological replicate 06 |
| GSM524906 |
Adrenal gland medullary hyperplasia, biological replicate 07 |
| GSM524907 |
Adrenal gland medullary hyperplasia, biological replicate 08 |
| GSM524908 |
Adrenal gland medulla pool 01 |
| GSM524909 |
Adrenal gland medulla pool 02 |
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| Relations |
| BioProject |
PRJNA125789 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE21006_RAW.tar |
40.3 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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