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| Status |
Public on Aug 12, 2022 |
| Title |
Target genes of thyroid hormone (TH) in white adipose tissue (WAT) and striatum and their role during metabolic stressors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We gathered in a single database available RNAseq and ChIPseq data to better characterize the target genes of the thyroid hormone receptors in several cell types. This database can serve as a resource to analyze the mode of action of the hormone. Also, it is an easy-handling convenient tool to obtain information on specific genes in regards to T3 regulation, or extract larger list of genes of interest based on the users’ criteria. Overall, this atlas is a unique compilation of recent sequencing data focusing on thyroid hormones, their receptors, mode of action, targets and roles which may profit researchers within the field. A preliminary analysis indicates extensive variations in the repertoire of target genes which transcription is upregulated by chromatin-bound nuclear receptor. Although it has a major influence, chromatin accessibility is not the only parameter that determines the cellular selectivity of hormonal response.
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| Overall design |
We performed high-throughput gene expression profiling of striatum and white adipose tissue (WAT) in hypothyroid mice (treated with PTU) after thyroid hormone (TH) treatment
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| Contributor(s) |
Zekri Y, Guyot R, Flamant F |
| Citation(s) |
36232747 |
| Submission date |
Aug 10, 2022 |
| Last update date |
Oct 31, 2022 |
| Contact name |
Yanis ZEKRI |
| E-mail(s) |
yanis.zekri@ens-lyon.fr
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| Organization name |
IGFL-ENS
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| Street address |
32-34 Avenue Tony Garnier
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| City |
Lyon |
| ZIP/Postal code |
69007 |
| Country |
France |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA868403 |
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