|
| Status |
Public on Mar 29, 2014 |
| Title |
Genome response to tissue plasminogen activator in experimental ischemic stroke |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
To further delineate tPA functions in the blood, we examined the gene expression profiles induced by tPA in a rat model of ischemic stroke.
Forty-two Sprague-Dawley rats were subjected to: 2 hours of middle cerebral artery occlusion (MCAO); a permanent-MCAO; or were used as controls. tPA was administered to half of the rats in each group at 3hours. Whole blood was drawn at 24 hours, and isolated RNA levels measured on Affymetrix Rat Genome 230 2.0 GeneChip microarrays to examine the entire RNA transcriptome.
|
| |
|
| Overall design |
42 samples, 7 groups in total ( 2 treatmented disease, 2 untreated disease, and 3 control groups), each group had 6 replicates
|
| |
|
| Citation(s) |
20406488 |
| Submission date |
Mar 30, 2010 |
| Last update date |
Mar 19, 2020 |
| Contact name |
Glen Jickling |
| E-mail(s) |
gcjickling@ucdavis.edu
|
| Organization name |
University of California Davis
|
| Street address |
2805 50th St
|
| City |
Sacramento |
| State/province |
CA |
| ZIP/Postal code |
95817 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
|
| Samples (42)
|
|
| Relations |
| BioProject |
PRJNA126651 |
Less...
More...