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| Status |
Public on Dec 01, 2022 |
| Title |
RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
NAFLD has become the most common chronic liver disease worldwide. Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key player in regulating lipid homeostasis in the liver and adipose tissues by using tissue-specific HuR knockout mice. However, the underlying mechanism by which hepatocyte-specific HuR regulates hepatic lipid metabolism under metabolic stress remains unclear and is the focus of this study.
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| Overall design |
Comparative gene expression profiling analysis for the livers of wild type mice and hepatocyte-specific HuR knockout mice fed Western Diet and sugar water.
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| Contributor(s) |
Wang Y, Tai Y, Way G, Zeng J, Zhao D, Su L, Jiang X, Cheng B, Wang X, Gurley EC, Liu J, Liu J, Chen W, Wang X, Sanyal AJ, Hylemon PB, Zhou H |
| Citation(s) |
36224648 |
| Submission date |
Sep 12, 2022 |
| Last update date |
Mar 02, 2023 |
| Contact name |
Huiping Zhou |
| E-mail(s) |
Huiping.zhou@vcuhealth.org
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| Organization name |
Virginia Commonwealth University
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| Department |
Department of Microbiology and Immunology
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| Lab |
Huiping Zhou Lab
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| Street address |
1220 East Broad Street
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| City |
Richmond |
| State/province |
VA |
| ZIP/Postal code |
23298 |
| Country |
USA |
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| Platforms (1) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA879761 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE213215_Total_Count-Sample_1-4.txt.gz |
282.1 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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