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Status |
Public on May 08, 2010 |
Title |
Expression data from mesothelial (LP9) and mesothelioma cells (HMESO) inhibited for extracellular-regulated kinase (ERK) 1, 2, or 5 |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Extracellular-regulated kinases (ERK1/2 and 5) are known to play important roles in growth and drug resistance of various cancers. Here we show roles of inhibition of ERK1, ERK2, or ERK5 on gene expression profiles of epithelioid malignant mesothelioma (MM) cells (HMESO).
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Overall design |
Untransfected human mesothelial cells (LP9), MM cells (HMESO) or HMESO cells stably transfected with shControl, shERK1, shERK2 , or shERK5 plasmids were used. Microarrays were performed on samples from 3 independent experiments. Each sample was analyzed on a separate array (3 independent biological replicates).
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Contributor(s) |
Shukla A |
Citation(s) |
21159167, 23446998 |
Submission date |
May 07, 2010 |
Last update date |
Dec 06, 2018 |
Contact name |
Arti Shukla |
E-mail(s) |
Arti.Shukla@uvm.edu
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Phone |
802-656-8253
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Organization name |
University of Vermont
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Department |
Pathology
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Lab |
215 HSRF
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Street address |
89 Beaumont Avenue
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City |
Burlington |
State/province |
VT |
ZIP/Postal code |
05405 |
Country |
USA |
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Platforms (1) |
GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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Samples (18)
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GSM542315 |
Malignant mesothelioma tumor cell line, rep1 |
GSM542316 |
Malignant mesothelioma tumor cell line, rep2 |
GSM542317 |
Malignant mesothelioma tumor cell line, rep3 |
GSM542318 |
MM line transfected with shCon, rep1 |
GSM542319 |
MM line transfected with shCon, rep2 |
GSM542320 |
MM line transfected with shCon, rep3 |
GSM542321 |
MM line transfected with shERK1, rep1 |
GSM542322 |
MM line transfected with shERK1, rep2 |
GSM542323 |
MM line transfected with shERK1, rep3 |
GSM542324 |
MM line transfected with shERK2, rep1 |
GSM542325 |
MM line transfected with shERK2, rep2 |
GSM542326 |
MM line transfected with shERK2, rep3 |
GSM1020014 |
MM line transfected with shERK5, rep 1 |
GSM1020015 |
MM line transfected with shERK5, rep 2 |
GSM1020016 |
MM line transfected with shERK5, rep 3 |
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Relations |
BioProject |
PRJNA127339 |
Supplementary file |
Size |
Download |
File type/resource |
GSE21750_RAW.tar |
39.3 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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