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| Status |
Public on Jan 01, 2013 |
| Title |
Genome-wide analysis of impact of B cells from the peripheral blood of chronic lymphocytic leukemia (CLL) patients versus B cells from healthy donors on CD14+ PBMCs from healthy donors |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
CD14+ cells in the PBMCs of CLL patients are converted into NLCs. CD14+ PBMCs from healthy donors when cultured with CLL cells give rise to differentiated cells called CD14CLL-cells, which are immunophenotypically similar to NLCs. CD14+ PBMCs from healthy donors when cultured with non-malignant B cells give rise to differentiated cells called CD14B-cells. Transcriptome wide analysis reveals genes involved in immune response to be significantly deregulated between CD14B-cells and CD14CLL-cells/NLCs.
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| |
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| Overall design |
Total RNA obtained from NLCs, CD14CLL-cells and CD14B-cells and hybridised to arrays (4 samples in each group)
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| |
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| Contributor(s) |
Bhattacharya N, Mertens D, Stilgenbauer S, Doehner H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 14, 2010 |
| Last update date |
Aug 16, 2018 |
| Contact name |
Nupur Bhattacharya |
| E-mail(s) |
nupur.bhattacharya@uniklinik-ulm.de
|
| Phone |
004973150045828
|
| Fax |
004973150045825
|
| Organization name |
University of Ulm
|
| Department |
Department of Internal Medicine III
|
| Street address |
Albert Einstein Allee 23
|
| City |
Ulm |
| ZIP/Postal code |
89081 |
| Country |
Germany |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA126923 |
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