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Series GSE21855 Query DataSets for GSE21855
Status Public on Jun 26, 2012
Title Elucidation of the expression profile of independent clones of mutant mtBALB and wild type control mtB6 murine cybrid cells
Organism Mus musculus
Experiment type Expression profiling by array
Summary We generated murine fibroblast cybrid cell lines that have identical nuclear genomes and differ only in their mtDNA. We observed increased cellular proliferation and resistance to apoptosis in the mtBALB compared to the mtB6 cybrid cells, phenotypes seen in malignant cells. Based on these observations we investigated whether these phenotypic differences could be caused by a unique spectrum of nuclear gene expression alterations induced by the mtDNA changes. Microarray analysis (Agilent, 44K mouse whole genome chip) was conducted in order to elucidate the expression profile of three independent clones of mtBALB and mtB6 cybrid cells.
 
Overall design Two-condition experiment, mtB6 vs. mtBALB cells. Biological replicates: 4 control replicates, 4 mutant replicates.
 
Contributor(s) Jandova J, Janda J, Sligh JE
Citation(s) 22705584
Submission date May 15, 2010
Last update date May 10, 2018
Contact name Jaroslav Janda
E-mail(s) jarek.janda@gmail.com
Phone 1 520 6265150
Organization name University of Arizona
Department Dept. of Medicine
Street address 1515 N Campbell Ave
City Tucson
State/province AZ
ZIP/Postal code 85724
Country USA
 
Platforms (1)
GPL4134 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version)
Samples (4)
GSM543623 Control mtB6 Cell Replicate 1 vs. Mutant mtBALB Cell Replicate 1
GSM543624 Control mtB6 Cell Replicate 2 vs. Mutant mtBALB Cell Replicate 2
GSM543625 Control mtB6 Cell Replicate 3 vs. Mutant mtBALB Cell Replicate 3
Relations
BioProject PRJNA127073

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE21855_RAW.tar 31.6 Mb (http)(custom) TAR (of GPR)
Processed data included within Sample table

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