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Series GSE2236 Query DataSets for GSE2236
Status Public on Feb 05, 2005
Title heart/muscle-specific MnSOD-deficient mouse
Organism Mus musculus
Experiment type Expression profiling by array
Summary To investigate the pathological significance of excess oxidative stress in the heart, we generated heart/muscle-specific manganese superoxide dismutase (MnSOD) -deficient mice on a C57BL/6 background using the Cre-loxP system uder the control of the muscle reatin kinase (MCK) promoter. The mutant mice developed progressive congestive heart failure with dilated cardiomyopathy and physical disability and died with a median survival rate of 15.4 ± 4.0 weeks. The pathological changes in our model were compatible with human cardiac aging. To investigate the transcriptional alterations in the mutant heart, we carried out an Affymetrix microarray analysis for comparison between the mutant and normal heart at 16 weeks of age.
Keywords = Mn-SOD
Keywords = manganese superoxide dismutase
Keywords = knockout
Keywords = heart failure
Keywords = heart
Keywords = muscle
Keywords: parallel sample
Contributor(s) Nojiri H, Shimizu T, Tachibana T, Ishikawa H, Ohta Y, Sami M, Kurosawa H, Kahn R, Shirasawa T
Citation(s) 16959785
Submission date Feb 03, 2005
Last update date Feb 11, 2019
Contact name Takuji Shirasawa
Phone +81-3-3964-3241
Fax +81-3-3579-4776
Organization name Tokyo Metropolitan Institute of Gerontology
Department Molecular Gerontology
Street address
City Itabashi-ku
State/province Tokyo
ZIP/Postal code 173-0015
Country Japan
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (4)
GSM40957 heart/muscle-specific MnSOD-deficient mouse (d/d)
GSM40958 heart/muscle-specific MnSOD-deficient mouse (d/d)
GSM40959 heart/muscle-specific MnSOD-deficient mouse (f/f)(control)
BioProject PRJNA91499

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