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| Status |
Public on Feb 05, 2005 |
| Title |
heart/muscle-specific MnSOD-deficient mouse |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To investigate the pathological significance of excess oxidative stress in the heart, we generated heart/muscle-specific manganese superoxide dismutase (MnSOD) -deficient mice on a C57BL/6 background using the Cre-loxP system uder the control of the muscle reatin kinase (MCK) promoter. The mutant mice developed progressive congestive heart failure with dilated cardiomyopathy and physical disability and died with a median survival rate of 15.4 ± 4.0 weeks. The pathological changes in our model were compatible with human cardiac aging. To investigate the transcriptional alterations in the mutant heart, we carried out an Affymetrix microarray analysis for comparison between the mutant and normal heart at 16 weeks of age.
Keywords = Mn-SOD
Keywords = manganese superoxide dismutase
Keywords = knockout
Keywords = heart failure
Keywords = heart
Keywords = muscle
Keywords: parallel sample
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| Contributor(s) |
Nojiri H, Shimizu T, Tachibana T, Ishikawa H, Ohta Y, Sami M, Kurosawa H, Kahn R, Shirasawa T |
| Citation(s) |
16959785 |
| Submission date |
Feb 03, 2005 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Takuji Shirasawa |
| E-mail(s) |
sirasawa@tmig.or.jp
|
| Phone |
+81-3-3964-3241
|
| Fax |
+81-3-3579-4776
|
| Organization name |
Tokyo Metropolitan Institute of Gerontology
|
| Department |
Molecular Gerontology
|
| Street address |
|
| City |
Itabashi-ku |
| State/province |
Tokyo |
| ZIP/Postal code |
173-0015 |
| Country |
Japan |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (4)
|
| GSM40957 |
heart/muscle-specific MnSOD-deficient mouse (d/d) |
| GSM40958 |
heart/muscle-specific MnSOD-deficient mouse (d/d) |
| GSM40959 |
heart/muscle-specific MnSOD-deficient mouse (f/f)(control) |
| GSM40960 |
heart/muscle-specific MnSOD-deficient mouse (f/f)(control) |
|
| Relations |
| BioProject |
PRJNA91499 |
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